![]() ![]() Much of the data and experience have been obtained from studies of TCA intoxication, but this appears to be generalizable to other forms of sodium channel blockade. This chapter will explore a broad approach to sodium channel blocker toxicity. Consequently, most patients who present with features of sodium channel blockade currently do not actually have TCA intoxication (but rather may have intoxication with other sodium blockers, such as cocaine or diphenhydramine). Consequently, TCA intoxication has become less common. With the increased use of selective serotonin reuptake inhibitors (SSRIs), the use of tricyclic antidepressants has decreased. TCAs are the original gangster of sodium channel blockade. However, a broad variety of other xenobiotics also block sodium channels, causing a similar pattern of findings. Tricyclic antidepressants (TCAs) are the perhaps the most widely discussed intoxicant which inhibits sodium channels (causing a characteristic pattern of QRS widening with a tall R-wave in aVR). Overview – sodium channel blockers & tricyclic antidepressants ![]()
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